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In Phase 3 trials, more than half of patients lost over 10% of their body weight in 6 months

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PennellDJPorterJBCappelliniMDChanLLEl-BeshlawyAAydinokYet alContinued improvement in myocardial T2* over two years of deferasirox therapy in -thalassemia Major patients with cardiac iron overload

As agonist dissociation within endosomes is a determinant of post-endocytic targeting to recycling or degradative pathways 44 , these observations may explain the contrasting recycling patterns of exendin-phe1 vs